Clinical significance of these preclinical data has not been established.
Formulated with stabilizing ingredients6-10
Poloxamer 407 and hypromellose help stabilize submicron particles, increasing contact with tears7-10
Similar to LOTEMAX® GEL, polycarbophil helps enhance widespread coverage and prolong exposure on the ocular surface to maximize absorption potential2
2. Rapid DISSOLUTION
Submicron particles have more surface area exposed to tears, driving rapid drug dissolution. In an in vitro assay, ~80% of maximum dissolved loteprednol etabonate was attained at 30 sec3-5
LOTEMAX® SM efficiently penetrates, with ~2x greater penetration to the aqueous humor than LOTEMAX® GEL (loteprednol etabonate ophthalmic gel) 0.5%2