Efficient absorption
Designed to adhere to the ocular surface and then penetrate key ocular tissues1,2
Clinical significance of these preclinical data has not been established.
Formulated with stabilizing ingredients5-7
Poloxamer 407 and hypromellose help stabilize submicron particles, increasing contact with tears6,7
1. Adherence
Similar to LOTEMAX® GEL, polycarbophil helps enhance widespread coverage and prolong exposure on the ocular surface to maximize absorption potential2
2. Rapid DISSOLUTION
Submicron particles have more surface area exposed to tears, driving rapid drug dissolution. In an in vitro assay, ~80% of maximum dissolved loteprednol etabonate was attained at 30 seconds3,4
3. Penetration
LOTEMAX® SM efficiently penetrates, with ~2x greater penetration to the aqueous humor than LOTEMAX® GEL (loteprednol etabonate ophthalmic gel) 0.5%2
OCULAR PENETRATION
Designed to improve drug exposure in key ocular
tissues, without increasing BAK1,4,5,7,*
Cmax=Peak drug concentration; AUC0-24=Drug exposure over 24 hours.
~2x GREATER PENETRATION
to the aqueous humor than LOTEMAX® GEL1
Clinical significance of these preclinical data has not been established.
*Compared to LOTEMAX® GEL.
Study Design: Preclinical study in 108 rabbits to examine the effect of submicron particle size on ocular tissue penetration and drug exposure. Ocular tissues included the conjunctiva, cornea, aqueous humor, and iris/ciliary body.